From the airport take I-195 west.

After less than 2 miles, take the MD-295 south exit (exit #2B) towards Washington.

After less than 3 miles, take the MD-100 west exit.

After about 8 miles, take the US-29 north exit towards I-70.

After about 3 miles, take the I-70 west exit towards Frederick.

After about 35 miles, take the US-340 west exit (exit # 52) towards Harpers Ferry.

After about 21 miles, turn right onto WV-230 north.

Stay on 230 for about 10 miles until it ends in Shepherdstown at the intersection of German and Duke Streets.  You will be at a 4-way stop intersection and the inn will be across the intersection, on the corner, to your left.  Make a left turn onto Duke Street and park either on the right side of the street next to the inn or in the gravel lot at the rear of the inn's yard.

The trip is a little over 80 miles and should take about 2 hours.