Get onto I-70 east.  I-70 intersects the PA turnpike and also I-68.

At the intersection I-70 and I-81 in Maryland, take I-81 south.

From I-81 take exit # 12 in West Virginia onto WV-9 east.

After about 2 miles, make a right turn onto WV-45 east towards Shepherdstown.

After about 8.5 miles WV-45 ends in Shepherdstown at the intersection of German and Duke Streets.  You will be at a 4-way stop intersection and the inn is located on the corner immediately to your right.  Make a right turn onto Duke Street and park either on the right side of the street next to the inn or in the gravel lot at the rear of the inn's yard.